The microbiome of pancreatic cancer: from molecular diagnostics to new therapeutic approaches to overcome chemoresistance caused by metabolic inactivation of gemcitabine.
Identifieur interne : 000706 ( Main/Exploration ); précédent : 000705; suivant : 000707The microbiome of pancreatic cancer: from molecular diagnostics to new therapeutic approaches to overcome chemoresistance caused by metabolic inactivation of gemcitabine.
Auteurs : Arthur T F. Choy [Pays-Bas] ; Ilaria Carnevale [Pays-Bas, Italie] ; Stefano Coppola [Pays-Bas] ; Laura L. Meijer [Pays-Bas] ; Geert Kazemier [Pays-Bas] ; Egija Zaura [Pays-Bas] ; Dongmei Deng [Pays-Bas] ; Elisa Giovannetti [Pays-Bas, Italie]Source :
- Expert review of molecular diagnostics [ 1744-8352 ] ; 2018.
Descripteurs français
- KwdFr :
- Aggregatibacter actinomycetemcomitans (génétique), Aggregatibacter actinomycetemcomitans (pathogénicité), Anatomopathologie moléculaire (MeSH), Animaux (MeSH), Cytidine deaminase (génétique), Désoxycytidine (analogues et dérivés), Désoxycytidine (effets indésirables), Désoxycytidine (usage thérapeutique), Gammaproteobacteria (effets des médicaments et des substances chimiques), Humains (MeSH), Inactivation métabolique (génétique), Parodontite chronique (génétique), Parodontite chronique (microbiologie), Porphyromonas gingivalis (pathogénicité), Récepteur Notch1 (génétique), Régulation de l'expression des gènes bactériens (effets des médicaments et des substances chimiques), Régulation de l'expression des gènes tumoraux (effets des médicaments et des substances chimiques), Résistance aux médicaments antinéoplasiques (génétique), Souris (MeSH), Tumeurs du pancréas (anatomopathologie), Tumeurs du pancréas (génétique), Tumeurs du pancréas (microbiologie), Tumeurs du pancréas (traitement médicamenteux).
- MESH :
- analogues et dérivés : Désoxycytidine.
- anatomopathologie : Tumeurs du pancréas.
- effets des médicaments et des substances chimiques : Gammaproteobacteria, Régulation de l'expression des gènes bactériens, Régulation de l'expression des gènes tumoraux.
- effets indésirables : Désoxycytidine.
- génétique : Aggregatibacter actinomycetemcomitans, Cytidine deaminase, Inactivation métabolique, Parodontite chronique, Récepteur Notch1, Résistance aux médicaments antinéoplasiques, Tumeurs du pancréas.
- microbiologie : Parodontite chronique, Tumeurs du pancréas.
- pathogénicité : Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis.
- traitement médicamenteux : Tumeurs du pancréas.
- usage thérapeutique : Désoxycytidine.
- Anatomopathologie moléculaire, Animaux, Humains, Souris.
English descriptors
- KwdEn :
- Aggregatibacter actinomycetemcomitans (genetics), Aggregatibacter actinomycetemcomitans (pathogenicity), Animals (MeSH), Chronic Periodontitis (genetics), Chronic Periodontitis (microbiology), Cytidine Deaminase (genetics), Deoxycytidine (adverse effects), Deoxycytidine (analogs & derivatives), Deoxycytidine (therapeutic use), Drug Resistance, Neoplasm (genetics), Gammaproteobacteria (drug effects), Gene Expression Regulation, Bacterial (drug effects), Gene Expression Regulation, Neoplastic (drug effects), Humans (MeSH), Inactivation, Metabolic (genetics), Mice (MeSH), Pancreatic Neoplasms (drug therapy), Pancreatic Neoplasms (genetics), Pancreatic Neoplasms (microbiology), Pancreatic Neoplasms (pathology), Pathology, Molecular (MeSH), Porphyromonas gingivalis (pathogenicity), Receptor, Notch1 (genetics).
- MESH :
- chemical , adverse effects : Deoxycytidine.
- chemical , analogs & derivatives : Deoxycytidine.
- chemical , genetics : Cytidine Deaminase, Receptor, Notch1.
- drug effects : Gammaproteobacteria, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Neoplastic.
- drug therapy : Pancreatic Neoplasms.
- genetics : Aggregatibacter actinomycetemcomitans, Chronic Periodontitis, Drug Resistance, Neoplasm, Inactivation, Metabolic, Pancreatic Neoplasms.
- microbiology : Chronic Periodontitis, Pancreatic Neoplasms.
- pathogenicity : Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis.
- pathology : Pancreatic Neoplasms.
- chemical , therapeutic use : Deoxycytidine.
- Animals, Humans, Mice, Pathology, Molecular.
Abstract
Introduction: Pancreatic cancer is a complex disease, with an extremely poor response to chemotherapy. Emerging evidence indicates that the tumor microenvironment (TME) might play an important role in mediating chemoresistance. Areas covered: The evaluated study by Geller and collaborators describes several bacterial species within pancreatic tumor tissues and TME and investigated their roles in gemcitabine chemoresistance. Intratumor bacteria express the enzyme cytidine deaminase (CDD), whose long form (CDDL) was shown to metabolize gemcitabine into its inactive metabolite. CDDL is mostly expressed by Gammaproteobacteria and this was among the most common species in pancreatic cancer tissues. Interestingly, mouse models of colorectal cancer injected with bacterial CDDL displayed a reduced response to gemcitabine, but this resistance was neutralized by the antibiotic ciprofloxacin. Expert Commentary: The increased knowledge on the microbiome in pancreatic tissues, as well as its role in chemoresistance, will provide innovative prognostic and therapeutic strategies.
DOI: 10.1080/14737159.2018.1544495
PubMed: 30392417
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Meijer</name><affiliation wicri:level="1"><nlm:affiliation>b Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>b Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>e Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>e Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation></author><author><name sortKey="Kazemier, Geert" sort="Kazemier, Geert" uniqKey="Kazemier G" first="Geert" last="Kazemier">Geert Kazemier</name><affiliation wicri:level="1"><nlm:affiliation>e Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>e Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation></author><author><name sortKey="Zaura, Egija" sort="Zaura, Egija" uniqKey="Zaura E" first="Egija" last="Zaura">Egija Zaura</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation></author><author><name sortKey="Deng, Dongmei" sort="Deng, Dongmei" uniqKey="Deng D" first="Dongmei" last="Deng">Dongmei Deng</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation></author><author><name sortKey="Giovannetti, Elisa" sort="Giovannetti, Elisa" uniqKey="Giovannetti E" first="Elisa" last="Giovannetti">Elisa Giovannetti</name><affiliation wicri:level="1"><nlm:affiliation>b Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>b Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>c Cancer Pharmacology Lab, AIRC Start-UP Unit , University of Pisa , Pisa , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>c Cancer Pharmacology Lab, AIRC Start-UP Unit , University of Pisa , Pisa </wicri:regionArea><wicri:noRegion>Pisa </wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30392417</idno><idno type="pmid">30392417</idno><idno type="doi">10.1080/14737159.2018.1544495</idno><idno type="wicri:Area/Main/Corpus">000663</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000663</idno><idno type="wicri:Area/Main/Curation">000663</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000663</idno><idno type="wicri:Area/Main/Exploration">000663</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The microbiome of pancreatic cancer: from molecular diagnostics to new therapeutic approaches to overcome chemoresistance caused by metabolic inactivation of gemcitabine.</title><author><name sortKey="Choy, Arthur T F" sort="Choy, Arthur T F" uniqKey="Choy A" first="Arthur T F" last="Choy">Arthur T F. Choy</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation></author><author><name sortKey="Carnevale, Ilaria" sort="Carnevale, Ilaria" uniqKey="Carnevale I" first="Ilaria" last="Carnevale">Ilaria Carnevale</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>b Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>b Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>c Cancer Pharmacology Lab, AIRC Start-UP Unit , University of Pisa , Pisa , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>c Cancer Pharmacology Lab, AIRC Start-UP Unit , University of Pisa , Pisa </wicri:regionArea><wicri:noRegion>Pisa </wicri:noRegion></affiliation></author><author><name sortKey="Coppola, Stefano" sort="Coppola, Stefano" uniqKey="Coppola S" first="Stefano" last="Coppola">Stefano Coppola</name><affiliation wicri:level="1"><nlm:affiliation>d Physics of Life Processes, Huygens-Kamerlingh Onnes Laboratory , Leiden University , Leiden , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>d Physics of Life Processes, Huygens-Kamerlingh Onnes Laboratory , Leiden University , Leiden </wicri:regionArea><wicri:noRegion>Leiden </wicri:noRegion></affiliation></author><author><name sortKey="Meijer, Laura L" sort="Meijer, Laura L" uniqKey="Meijer L" first="Laura L" last="Meijer">Laura L. Meijer</name><affiliation wicri:level="1"><nlm:affiliation>b Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>b Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>e Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>e Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation></author><author><name sortKey="Kazemier, Geert" sort="Kazemier, Geert" uniqKey="Kazemier G" first="Geert" last="Kazemier">Geert Kazemier</name><affiliation wicri:level="1"><nlm:affiliation>e Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>e Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation></author><author><name sortKey="Zaura, Egija" sort="Zaura, Egija" uniqKey="Zaura E" first="Egija" last="Zaura">Egija Zaura</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation></author><author><name sortKey="Deng, Dongmei" sort="Deng, Dongmei" uniqKey="Deng D" first="Dongmei" last="Deng">Dongmei Deng</name><affiliation wicri:level="1"><nlm:affiliation>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation></author><author><name sortKey="Giovannetti, Elisa" sort="Giovannetti, Elisa" uniqKey="Giovannetti E" first="Elisa" last="Giovannetti">Elisa Giovannetti</name><affiliation wicri:level="1"><nlm:affiliation>b Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>b Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam </wicri:regionArea><wicri:noRegion>Amsterdam </wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>c Cancer Pharmacology Lab, AIRC Start-UP Unit , University of Pisa , Pisa , Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>c Cancer Pharmacology Lab, AIRC Start-UP Unit , University of Pisa , Pisa </wicri:regionArea><wicri:noRegion>Pisa </wicri:noRegion></affiliation></author></analytic><series><title level="j">Expert review of molecular diagnostics</title><idno type="eISSN">1744-8352</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aggregatibacter actinomycetemcomitans (genetics)</term><term>Aggregatibacter actinomycetemcomitans (pathogenicity)</term><term>Animals (MeSH)</term><term>Chronic Periodontitis (genetics)</term><term>Chronic Periodontitis (microbiology)</term><term>Cytidine Deaminase (genetics)</term><term>Deoxycytidine (adverse effects)</term><term>Deoxycytidine (analogs & derivatives)</term><term>Deoxycytidine (therapeutic use)</term><term>Drug Resistance, Neoplasm (genetics)</term><term>Gammaproteobacteria (drug effects)</term><term>Gene Expression Regulation, Bacterial (drug effects)</term><term>Gene Expression Regulation, Neoplastic (drug effects)</term><term>Humans (MeSH)</term><term>Inactivation, Metabolic (genetics)</term><term>Mice (MeSH)</term><term>Pancreatic Neoplasms (drug therapy)</term><term>Pancreatic Neoplasms (genetics)</term><term>Pancreatic Neoplasms (microbiology)</term><term>Pancreatic Neoplasms (pathology)</term><term>Pathology, Molecular (MeSH)</term><term>Porphyromonas gingivalis (pathogenicity)</term><term>Receptor, Notch1 (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Aggregatibacter actinomycetemcomitans (génétique)</term><term>Aggregatibacter actinomycetemcomitans (pathogénicité)</term><term>Anatomopathologie moléculaire (MeSH)</term><term>Animaux (MeSH)</term><term>Cytidine deaminase (génétique)</term><term>Désoxycytidine (analogues et dérivés)</term><term>Désoxycytidine (effets indésirables)</term><term>Désoxycytidine (usage thérapeutique)</term><term>Gammaproteobacteria (effets des médicaments et des substances chimiques)</term><term>Humains (MeSH)</term><term>Inactivation métabolique (génétique)</term><term>Parodontite chronique (génétique)</term><term>Parodontite chronique (microbiologie)</term><term>Porphyromonas gingivalis (pathogénicité)</term><term>Récepteur Notch1 (génétique)</term><term>Régulation de l'expression des gènes bactériens (effets des médicaments et des substances chimiques)</term><term>Régulation de l'expression des gènes tumoraux (effets des médicaments et des substances chimiques)</term><term>Résistance aux médicaments antinéoplasiques (génétique)</term><term>Souris (MeSH)</term><term>Tumeurs du pancréas (anatomopathologie)</term><term>Tumeurs du pancréas (génétique)</term><term>Tumeurs du pancréas (microbiologie)</term><term>Tumeurs du pancréas (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Deoxycytidine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Deoxycytidine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cytidine Deaminase</term><term>Receptor, Notch1</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Désoxycytidine</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gammaproteobacteria</term><term>Gene Expression Regulation, Bacterial</term><term>Gene Expression Regulation, Neoplastic</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Gammaproteobacteria</term><term>Régulation de l'expression des gènes bactériens</term><term>Régulation de l'expression des gènes tumoraux</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Désoxycytidine</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Aggregatibacter actinomycetemcomitans</term><term>Chronic Periodontitis</term><term>Drug Resistance, Neoplasm</term><term>Inactivation, Metabolic</term><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Aggregatibacter actinomycetemcomitans</term><term>Cytidine deaminase</term><term>Inactivation métabolique</term><term>Parodontite chronique</term><term>Récepteur Notch1</term><term>Résistance aux médicaments antinéoplasiques</term><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Parodontite chronique</term><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Chronic Periodontitis</term><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Aggregatibacter actinomycetemcomitans</term><term>Porphyromonas gingivalis</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Aggregatibacter actinomycetemcomitans</term><term>Porphyromonas gingivalis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Pancreatic Neoplasms</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Deoxycytidine</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs du pancréas</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Désoxycytidine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Mice</term><term>Pathology, Molecular</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Anatomopathologie moléculaire</term><term>Animaux</term><term>Humains</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><b>Introduction</b>: Pancreatic cancer is a complex disease, with an extremely poor response to chemotherapy. Emerging evidence indicates that the tumor microenvironment (TME) might play an important role in mediating chemoresistance. <b>Areas covered</b>: The evaluated study by Geller and collaborators describes several bacterial species within pancreatic tumor tissues and TME and investigated their roles in gemcitabine chemoresistance. Intratumor bacteria express the enzyme cytidine deaminase (CDD), whose long form (CDD<sub>L</sub>) was shown to metabolize gemcitabine into its inactive metabolite. CDD<sub>L</sub> is mostly expressed by <i>Gammaproteobacteria</i> and this was among the most common species in pancreatic cancer tissues. Interestingly, mouse models of colorectal cancer injected with bacterial CDD<sub>L</sub> displayed a reduced response to gemcitabine, but this resistance was neutralized by the antibiotic ciprofloxacin. <b>Expert Commentary</b>: The increased knowledge on the microbiome in pancreatic tissues, as well as its role in chemoresistance, will provide innovative prognostic and therapeutic strategies.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30392417</PMID><DateCompleted><Year>2019</Year><Month>10</Month><Day>14</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1744-8352</ISSN><JournalIssue CitedMedium="Internet"><Volume>18</Volume><Issue>12</Issue><PubDate><Year>2018</Year><Month>12</Month></PubDate></JournalIssue><Title>Expert review of molecular diagnostics</Title><ISOAbbreviation>Expert Rev Mol Diagn</ISOAbbreviation></Journal><ArticleTitle>The microbiome of pancreatic cancer: from molecular diagnostics to new therapeutic approaches to overcome chemoresistance caused by metabolic inactivation of gemcitabine.</ArticleTitle><Pagination><MedlinePgn>1005-1009</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/14737159.2018.1544495</ELocationID><Abstract><AbstractText><b>Introduction</b>: Pancreatic cancer is a complex disease, with an extremely poor response to chemotherapy. Emerging evidence indicates that the tumor microenvironment (TME) might play an important role in mediating chemoresistance. <b>Areas covered</b>: The evaluated study by Geller and collaborators describes several bacterial species within pancreatic tumor tissues and TME and investigated their roles in gemcitabine chemoresistance. Intratumor bacteria express the enzyme cytidine deaminase (CDD), whose long form (CDD<sub>L</sub>) was shown to metabolize gemcitabine into its inactive metabolite. CDD<sub>L</sub> is mostly expressed by <i>Gammaproteobacteria</i> and this was among the most common species in pancreatic cancer tissues. Interestingly, mouse models of colorectal cancer injected with bacterial CDD<sub>L</sub> displayed a reduced response to gemcitabine, but this resistance was neutralized by the antibiotic ciprofloxacin. <b>Expert Commentary</b>: The increased knowledge on the microbiome in pancreatic tissues, as well as its role in chemoresistance, will provide innovative prognostic and therapeutic strategies.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Choy</LastName><ForeName>Arthur T F</ForeName><Initials>ATF</Initials><AffiliationInfo><Affiliation>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam , The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carnevale</LastName><ForeName>Ilaria</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam , The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>c Cancer Pharmacology Lab, AIRC Start-UP Unit , University of Pisa , Pisa , Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Coppola</LastName><ForeName>Stefano</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>d Physics of Life Processes, Huygens-Kamerlingh Onnes Laboratory , Leiden University , Leiden , The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meijer</LastName><ForeName>Laura L</ForeName><Initials>LL</Initials><AffiliationInfo><Affiliation>b Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>e Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kazemier</LastName><ForeName>Geert</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>e Department of Surgery, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zaura</LastName><ForeName>Egija</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam , The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Deng</LastName><ForeName>Dongmei</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>a Department of Preventive Dentistry , Academic Centre for Dentistry Amsterdam (ACTA) , Amsterdam , The Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Giovannetti</LastName><ForeName>Elisa</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>b Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam UMC , VU University Amsterdam , Amsterdam , The Netherlands.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>c Cancer Pharmacology Lab, AIRC Start-UP Unit , University of Pisa , Pisa , Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>11</Month><Day>09</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Expert Rev Mol Diagn</MedlineTA><NlmUniqueID>101120777</NlmUniqueID><ISSNLinking>1473-7159</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051881">Receptor, Notch1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0W860991D6</RegistryNumber><NameOfSubstance UI="D003841">Deoxycytidine</NameOfSubstance></Chemical><Chemical><RegistryNumber>B76N6SBZ8R</RegistryNumber><NameOfSubstance UI="C056507">gemcitabine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.5.4.5</RegistryNumber><NameOfSubstance UI="D003564">Cytidine Deaminase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D016976" MajorTopicYN="N">Aggregatibacter actinomycetemcomitans</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055113" MajorTopicYN="N">Chronic Periodontitis</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003564" MajorTopicYN="N">Cytidine Deaminase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003841" MajorTopicYN="N">Deoxycytidine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019008" MajorTopicYN="N">Drug Resistance, Neoplasm</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020563" MajorTopicYN="N">Gammaproteobacteria</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015964" MajorTopicYN="N">Gene Expression Regulation, Bacterial</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015972" MajorTopicYN="N">Gene Expression Regulation, Neoplastic</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008658" MajorTopicYN="N">Inactivation, Metabolic</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010190" MajorTopicYN="N">Pancreatic Neoplasms</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000382" MajorTopicYN="Y">microbiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D057089" MajorTopicYN="N">Pathology, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016966" MajorTopicYN="N">Porphyromonas gingivalis</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051881" MajorTopicYN="N">Receptor, Notch1</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Aggregatibacter actinomycetemcomitans</Keyword><Keyword MajorTopicYN="Y">Notch-1</Keyword><Keyword MajorTopicYN="Y">Porphyromonas gingivalis</Keyword><Keyword MajorTopicYN="Y">chronic periodontitis</Keyword><Keyword MajorTopicYN="Y">cytidine deaminase</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>10</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>11</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">30392417</ArticleId><ArticleId IdType="doi">10.1080/14737159.2018.1544495</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li><li>Pays-Bas</li></country></list><tree><country name="Pays-Bas"><noRegion><name sortKey="Choy, Arthur T F" sort="Choy, Arthur T F" uniqKey="Choy A" first="Arthur T F" last="Choy">Arthur T F. Choy</name></noRegion><name sortKey="Carnevale, Ilaria" sort="Carnevale, Ilaria" uniqKey="Carnevale I" first="Ilaria" last="Carnevale">Ilaria Carnevale</name><name sortKey="Carnevale, Ilaria" sort="Carnevale, Ilaria" uniqKey="Carnevale I" first="Ilaria" last="Carnevale">Ilaria Carnevale</name><name sortKey="Coppola, Stefano" sort="Coppola, Stefano" uniqKey="Coppola S" first="Stefano" last="Coppola">Stefano Coppola</name><name sortKey="Deng, Dongmei" sort="Deng, Dongmei" uniqKey="Deng D" first="Dongmei" last="Deng">Dongmei Deng</name><name sortKey="Giovannetti, Elisa" sort="Giovannetti, Elisa" uniqKey="Giovannetti E" first="Elisa" last="Giovannetti">Elisa Giovannetti</name><name sortKey="Kazemier, Geert" sort="Kazemier, Geert" uniqKey="Kazemier G" first="Geert" last="Kazemier">Geert Kazemier</name><name sortKey="Meijer, Laura L" sort="Meijer, Laura L" uniqKey="Meijer L" first="Laura L" last="Meijer">Laura L. Meijer</name><name sortKey="Meijer, Laura L" sort="Meijer, Laura L" uniqKey="Meijer L" first="Laura L" last="Meijer">Laura L. Meijer</name><name sortKey="Zaura, Egija" sort="Zaura, Egija" uniqKey="Zaura E" first="Egija" last="Zaura">Egija Zaura</name></country><country name="Italie"><noRegion><name sortKey="Carnevale, Ilaria" sort="Carnevale, Ilaria" uniqKey="Carnevale I" first="Ilaria" last="Carnevale">Ilaria Carnevale</name></noRegion><name sortKey="Giovannetti, Elisa" sort="Giovannetti, Elisa" uniqKey="Giovannetti E" first="Elisa" last="Giovannetti">Elisa Giovannetti</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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